Abstract #1158
Exploring the Biomechanical Properties of Brain Malignancies and their Pathological Determinants with Magnetic Resonance Elastography
Jin Li 1 , Yann Jamin 1 , Jessica K.R. Boult 1 , Philippe Garteiser 2 , Jose L. Ulloa 3 , Sergey Popov 4,5 , Craig Cummings 1 , Gary Box 5 , Suzanne A. Eccles 5 , Chris Jones 4,5 , John C. Waterton 3 , Jeffrey C. Bamber 1 , Ralph Sinkus 2,6 , and Simon P. Robinson 1
1
Division of Radiotherapy & Imaging, The
Institute of Cancer Research, Sutton, Surrey, United
Kingdom,
2
INSERM
U773, CRB3, Centre de Recherches Biomdicales
Bichat-Beaujon, France,
3
Personalised
Healthcare and Biomarkers, AstraZeneca, Macclesfield,
Cheshire, United Kingdom,
4
Division
of Molecular Pathology, The Institute of Cancer
Research, Sutton, Surrey, United Kingdom,
5
Division
of Cancer Therapeutics, The Institute of Cancer
Research, Sutton, Surrey, United Kingdom,
6
BHF
Centre of Excellence, Division of Imaging Sciences and
Biomedical Engineering, King's College London, King's
Health Partners, St Thomas' Hospital, London, United
Kingdom
Recently MRE revealed that tumours derived from human
breast adenocarcinoma MDA-MB-231, rat Glioma RG2 or
human gioblastoma U87-MG cells were softer than healthy
brain tissue, with MDA-MB-231 significantly softer and
less viscous than the other two models. We investigated
the cellular density, microvessel density, myelin
content and collagen content in these models, and showed
that between the tumours, in MDA-MB-231 tumours, cell
density and microvessel density were significantly lower
than the other two models, positive correlated with
MRE-derived elasticity and viscosity. Meanwhile, the
lack of anisotropic structure of intracranial tumours
may underpin their relative softness.
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