Multiparametric characterization of the sex differences in a high-grade glioma rat model by in vivo magnetic resonance and post-mortem analysis.
, Omar Cauli
and Pilar Lopez-Larrubia
Department of Experimental models of human
diseases, Instituto de Investigaciones Biomdicas,
CSIC-UAM, Madrid, Spain,
of Nursing, University of Valencia, Valencia, Spain
Despite there is a clear predominance in cerebral tumors
in male, gender differences are not usually considered
either in the behavioural characterization or new
therapies development in brain oncology. In the present
work we used an animal model of high-grade glioma to
assess in vivo and ex vivo the gender dependence of MR
and biological parameters. Glioma bearing female rats
showed more extended necrosis in tumors than males,
while the latters present higher disruption of the blood
brain barrier. We indicate the ability of using MR
surrogate markers to signal and track the gender
dependence in brain tumorigenesis.
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