Multiparametric characterization of the sex differences in a high-grade glioma rat model by in vivo magnetic resonance and post-mortem analysis.

Despite there is a clear predominance in cerebral tumors in male, gender differences are not usually considered either in the behavioural characterization or new therapies development in brain oncology. In the present work we used an animal model of high-grade glioma to assess in vivo and ex vivo the gender dependence of MR and biological parameters. Glioma bearing female rats showed more extended necrosis in tumors than males, while the latters present higher disruption of the blood brain barrier. We indicate the ability of using MR surrogate markers to signal and track the gender dependence in brain tumorigenesis.

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