Monte Carlo Simulation of the Effect of Fat Spatial Distribution in Trabecular Bone Marrow on the DDIF MR Signal
Sara Maria Sprinkhuizen 1 , Jerome Ackerman 1 , and Yi-Qiao Song 1,2
MGH/HST Athinoula A. Martinos Center for
Biomedical Imaging, Charlestown, MA, United States,
Research, Cambridge, MA, United States
Decay due to Diffusion in the Internal Field (DDIF) MRI
measures solid trabecular bone structures. Bone marrow
plays an important role in DDIF MRI: the magnetic
susceptibility of marrow fat induces field gradients in
the pore spaces which depend on the water-fat ratio and
spatial distribution of the fat cells within the pores.
In this work we assessed whether DDIF MRI technique may
be used to detect bone marrow alterations and diseases.
As a first step towards this goal, we simulated the
effect of the spatial distribution of marrow fat cells
on the DDIF MRI signal for 3 clinical cases.
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