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Abstract #1194

Significant Influences of Loading on T1 in Sub-tissue Zones of Canine Articular Cartilage in Experimental OA

Jihyun Lee 1 and Yang Xia 1

1 Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan, United States

This study aims to quantify the loading-modified topographical and zonal T1 in articular cartilage in early experimental canine OA using MRI at the 17.6m resolution and when the tissue was soaked with the Gd contrast agent. Both OA and mechanical compression were found to be able to alter the T1 relaxation time of articular cartilage at each sub-tissue zone and topographically, which provide a better understanding of the MRI properties of cartilage during joint loading. This result could help to design effective protocols in clinical MRI to better detect and manage the articular diseases.

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