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Abstract #1200

Registration-Based Motion Correction in Time-Series Studies of Bone Microarchitecture and Mechanics

Ning Zhang 1 , Jeremy F Magland 1 , Chamith S Rajapakse 1 , Hee Kwon Song 1 , and Felix W Wehrli 1

1 University of Pennsylvania, Philadelphia, PA, United States

Subject motion degrades image quality. Intra-scan subject motion can further mask detectability of treatment effects in time-series studies. Here we present a registration-based technique designed to retrospectively correct for rigid-body intra-scan subject motion. Results from in-vivo micro-MR images of the distal radius show significant improvements in both image quality and serial reproducibility on image-derived trabecular bone micro-structure and biomechanics compared to the navigator-based and autofocusing techniques.

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