Abstract #1218
Assessment of inflammatory Component in the Mono-Iodoacetate (MIA) Model of Osteoarthritis by MRI
Thomas Kaulisch 1 , Laura Corradini 2 , and Detlef Stiller 3
1
Target Discovery Research, Boehringer
Ingelheim Pharma GmbH & Co. KG, Biberach,
Baden-Wrttemberg, Germany,
2
CNS
Diseases Research, Boehringer Ingelheim Pharma GmbH &
Co. KG, Baden-Wrttemberg, Germany,
3
Target
Discovery Research, Boehringer Ingelheim Pharma GmbH &
Co. KG, Baden-Wrttemberg, Germany
The Mono-Iodoacetate (MIA) model is an attractive tool
for testing novel compounds at different stages of
progressive osteoarthritis (OA) development. We
characterize the inflammatory component by means of
MRI-based volumetry and DCE-MRI and demonstrate
treatment effects when using Celecoxib.
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