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Abstract #1224

Effect of Anisotropic Smoothing on DT-MRI-based Fiber Tractography in the Medial Gastrocnemius Muscle

Amanda K. W. Buck 1 , Zhaohua Ding 1,2 , Christopher P. Elder 1 , Theodore F. Towse 1,3 , and Bruce M. Damon 1

1 Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2 Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States, 3 Physical Medicine and Rehabilitation, Vanderbilt University, Nashville, TN, United States

DT-MRI-based fiber tractography allows non-invasive estimation of three-dimensional muscle architecture; however, DT-MRI in the leg suffers from low SNR, which can introduce error in the estimation of diffusion tensor eigenvectors used for tract propogation. This study assesses the effect of anisotropic smoothing on fiber tracking measures in the medial gastrocnemius muscle in healthy subjects.

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