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Abstract #1228

NMR based biomarkers to study aging related changes in the human quadriceps

Noura Azzabou 1 , Jean-Yves Hogrel 2 , Yoann Barnouin 2 , and Pierre G Carlier 1

1 AIM-CEA Institut de Myologie, Laboratoire RMN, Paris, France, 2 AIM, Institut de Myologie, Laboratoire de physiologie et d'valuation neuromusculaire, Paris, France

In order to study the impact of aging on the skeletal muscle, we suggested several NMR based parameters that are water T2 values and heterogeneity indices related to water T2 changes. We evaluated this parameter on the quadriceps muscles of healthy young adults and older one. In addition to age, we considered the gender and physical activity factors. Results showed that water T2, and heterogeneities were higher for elderly group. Furthermore, a regular physical activity maintained lower muscle T2 values and heterogeneity indices. These findings may be related to the progressive atrophy and rarefaction of type II fibers with age.

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