NMR based biomarkers to study aging related changes in the human quadriceps
Noura Azzabou 1 , Jean-Yves Hogrel 2 , Yoann Barnouin 2 , and Pierre G Carlier 1
AIM-CEA Institut de Myologie, Laboratoire
RMN, Paris, France,
Institut de Myologie, Laboratoire de physiologie et
d'valuation neuromusculaire, Paris, France
In order to study the impact of aging on the skeletal
muscle, we suggested several NMR based parameters that
are water T2 values and heterogeneity indices related to
water T2 changes. We evaluated this parameter on the
quadriceps muscles of healthy young adults and older
one. In addition to age, we considered the gender and
physical activity factors. Results showed that water T2,
and heterogeneities were higher for elderly group.
Furthermore, a regular physical activity maintained
lower muscle T2 values and heterogeneity indices. These
findings may be related to the progressive atrophy and
rarefaction of type II fibers with age.
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