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Abstract #1235

Characterization of Metabolic Response to Ischemia in Skeletal Muscle of Non-obese Early Stage Type 2 Diabetic Rats by in vivo 31P MRS and BOLD MRI

Yuchi Liu 1 , Xunbai Mei 1 , Nicola Lai 1,2 , and Xin Yu 1,3

1 Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States, 2 Pediatrics, Case Western Reserve University, Ohio, United States, 3 Radiology, Case Western Reserve University, Ohio, United States

This study investigated the metabolic response to ischemia in skeletal muscle of non-obese early stage type 2 diabetic rats. 31P spectra and BOLD images were acquired in an interleaved fashion at baseline, during 25-min ischemia, and 20-min reperfusion. The diabetic group showed less reduction in phosphocreatine (PCr) and less increase in inorganic phosphate (Pi) during ischemia. Diabetic rats also showed greater signal reduction in BOLD images during ischemia, possibly due to increased oxygen extraction. Both diabetic and control groups have similar PCr recovery kinetics during reperfusion. These data suggest that mitochondrial function may remain normal in early stage type 2 diabetes.

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