Abstract #1249
Pharmacokinetic analysis of DCE-MRI data from lumbar spine reveals pathologic changes in intervertebral disc endplates and subchondral bone
Volkan Emre Arpinar 1 , Dennis J Maiman 1 , and L Tugan Muftuler 1,2
1
Department of Neurosurgery, Medical College
of Wisconsin, Milwaukee, WI, United States,
2
Center
for Imaging Research, Medical College of Wisconsin, WI,
United States
The majority of chronic back pain is associated with
degeneration of the intervertebral discs. Despite
comprehensive studies, there is no consensus on the
mechanisms of pathological degeneration or how it should
be distinguished from the normal aging processes. One of
the causes of degeneration is believed to be poor
nutrient transport to the disc through the endplates. In
this study, Dynamic Contrast Enhanced MRI was used to
investigate the relation between disc degeneration and
aberrations in nutrient transport to the discs. A
compartmental model with standard kinetic parameters was
implemented to study perfusion in endplates and adjacent
subchondral bones.
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