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Abstract #1265

Magic Angle Enhanced MR Microscopy of Fibrous Structures in Normotensive and Hypertensive Eyes using T2, T2* and T1rho MRI

Leon C. Ho 1,2 , Ian A. Sigal 3 , Ning-Juan Jan 3 , Hunter Mehrens 1 , Alexander Squires 4 , Zion Tse 4 , Ed X Wu 2 , Joel S. Schuman 3 , Seong-Gi Kim 1,5 , Tao Jin 1 , and Kevin C Chan 1,3

1 Neuroimaging Laboratory, Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong, China, 3 Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 4 Medical Robotics Lab, College of Engineering, The University of Georgia, Athens, Georgia, United States, 5 Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Dept. of Biological Sci, SKKU, Suwon, Korea

Sclera is a fibrous connective tissue in the outer coat of the eye which may undergo microscopic structural reorganization under different physiological environments. Ocular hypertension may apply tensile stress to sclera leading to microstructural changes. However, there are limited non-invasive technique available. In this study, we demonstrated the feasibility of using magic angle enhanced MRI in different MR contrasts to detect magnetic tissue property changes in scleral fibers of and normotensive and hypertenive eyes.

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