Abstract #1265
Magic Angle Enhanced MR Microscopy of Fibrous Structures in Normotensive and Hypertensive Eyes using T2, T2* and T1rho MRI
Leon C. Ho 1,2 , Ian A. Sigal 3 , Ning-Juan Jan 3 , Hunter Mehrens 1 , Alexander Squires 4 , Zion Tse 4 , Ed X Wu 2 , Joel S. Schuman 3 , Seong-Gi Kim 1,5 , Tao Jin 1 , and Kevin C Chan 1,3
1
Neuroimaging Laboratory, Department of
Radiology, University of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Pokfulam, Hong Kong, China,
3
Department
of Ophthalmology, University of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
4
Medical Robotics
Lab, College of Engineering, The University of Georgia,
Athens, Georgia, United States,
5
Center
for Neuroscience Imaging Research, Institute for Basic
Science (IBS), Dept. of Biological Sci, SKKU, Suwon,
Korea
Sclera is a fibrous connective tissue in the outer coat
of the eye which may undergo microscopic structural
reorganization under different physiological
environments. Ocular hypertension may apply tensile
stress to sclera leading to microstructural changes.
However, there are limited non-invasive technique
available. In this study, we demonstrated the
feasibility of using magic angle enhanced MRI in
different MR contrasts to detect magnetic tissue
property changes in scleral fibers of and normotensive
and hypertenive eyes.
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