Meeting Banner
Abstract #1278

23 Na Magnetic Resonance Spectroscopic Imaging (MRSI) on a High-Density 3d-cell culture on chip (3 D -KITChip)

Andreas Neubauer 1 , Michaela Ruttorf 1 , Raffi Kalaycian 1 , Jan Sachs 1 , Cordula Nies 2 , Stefan Giselbrecht 2 , Eric Gottwald 2 , and Lothar Schad 1

1 Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Wuertemberg, Germany, 2 Institute for Biological Interfaces-1, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Baden-Wuertemberg, Germany

In this study we present a setup capable to monitor changes in ionic concentration gradients in vitro . The main parts of the setup are a three dimensional cell culture, a completely MR-compatible bioreactor and a 23 Na surface coil. In a pilot study we performd a 23 Na CSI experiment to show that we are able to resolve a non varying reference compartment from a compartment with varying physiological parameters.

This abstract and the presentation materials are available to members only; a login is required.

Join Here