Abstract #1278
23 Na Magnetic Resonance Spectroscopic Imaging (MRSI) on a High-Density 3d-cell culture on chip (3 D -KITChip)
Andreas Neubauer 1 , Michaela Ruttorf 1 , Raffi Kalaycian 1 , Jan Sachs 1 , Cordula Nies 2 , Stefan Giselbrecht 2 , Eric Gottwald 2 , and Lothar Schad 1
1
Computer Assisted Clinical Medicine, Medical
Faculty Mannheim, Heidelberg University, Mannheim,
Baden-Wuertemberg, Germany,
2
Institute
for Biological Interfaces-1, Karlsruhe Institute of
Technology, Eggenstein-Leopoldshafen, Baden-Wuertemberg,
Germany
In this study we present a setup capable to monitor
changes in ionic concentration gradients
in
vitro
. The main parts of the setup are a
three
dimensional
cell
culture, a completely MR-compatible bioreactor and a
23
Na
surface coil. In a pilot study we performd a
23
Na
CSI experiment to show that we are able to resolve a non
varying reference compartment from a compartment with
varying physiological parameters.
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