Abstract #1298
Development of an MRI method for awake mouse imaging using soft immobilization and a fast MR acquisition procedure
Shunsuke Kusanagi 1 , Kazunari Kimura 1 , Makoto Hirakane 1 , Shigeto Iwamoto 1 , Rikita Araki 2 , Sosuke Yoshinaga 1 , and Hiroaki Terasawa 1
1
Faculty of Life Sciences, Kumamoto
University, Kumamoto, Japan,
2
Bruker
Biospin K.K., Yokohama, Kanagawa, Japan
Mouse MRI studies facilitate the elucidation of the
pathogenic mechanisms underlying various diseases and
the appropriate medical treatments, due to the
remarkable advances in mouse genetic technology. It is
difficult to acquire accurate MR images when an imaging
target moves in the scanner, and thus treatment with
anesthesia and fixing apparatuses are usually required.
However, the brain activation profiles were reportedly
affected by anesthesia. To exclude the unfavorable
anesthetic effects, we successfully developed an
easy-to-operate method for awake mouse brain imaging,
which uses softer immobilization with clothes for mice
and a fast MR acquisition procedure, without surgery and
training.
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