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Abstract #1396

Validation of a PET-derived Respiratory Signal by Comparison with an MRI Pencil-Beam Navigator Signal in Simultaneous PET/MR

Richard Manber 1 , David Atkinson 1 , Anna Barnes 2 , Brian Hutton 1 , Celia O'Meara 2 , Sebastien Ourselin 1 , Simon Arridge 1 , and Kris Thielemans 1

1 University College London, London, United Kingdom, 2 University College London Hospital, London, United Kingdom

Respiratory gating in PET imaging is common practice to correct for motion. It has previously been shown that a respiratory signal can be extracted from PET list-mode data using Principal Component Analysis (PCA). We demonstrate the validity of this signal by showing a strong correlation with the gold-standard MRI navigator signal, simultaneously acquired on 9 patients with a range of PET tracers, and by showing comparable PET gating results based on the PET and MRI derived respiratory signals respectively. Finally we show improvements in image sharpness of motion corrected images, formed by warping and combining gates.

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