Abstract #1492
On the application of simultaneous dual contrast weighting using double echo 2in1-RARE in healthy subjects and multiple sclerosis patients
Katharina Fuchs 1 , Fabian Hezel 1 , Sabrina Klix 1 , Ralf Mekle 2 , Jens Wuerfel 3,4 , and Thoralf Niendorf 1,5
1
Berlin Ultrahigh Field Facility (B.U.F.F.),
Max-Delbrueck Center for Molecular Medicine, Berlin,
Germany,
2
Medical
Metrology, Physikalisch Technische Bundesanstalt,
Berlin, Germany,
3
Institute
of Neuroradiology, University Medicine Goettingen,
Germany,
4
NeuroCure
Clinical Research Center, Charit - University Medicine
Berlin, Germany,
5
Experimental and Clinical
Research Center (ECRC), a joint cooperation between the
Charit Medical Faculty and the Max-Delbrueck Center,
Berlin, Germany
2in1-RARE is a RARE variant which is simultaneously
sensitive to T
2
*
and
proton density contrast. This is achieved by strictly
separating spin echo and stimulated echo magnetization
within a RARE echo train. The performance of 2in1-RARE
is elucidated using point spread function assessment.
2in1-RARE traits for T
2
*
mapping
are validated against conventional mulit-echo gradient
echo acquisitions. The applicability of dual contrast
weighted double echo 2in1-RARE is demonstrated for brain
imaging using susceptibility weighted imaging, T
2
*
mapping
and proton density weighted imaging in healthy subjects
and multiple sclerosis patients.
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