Neuroimaging with INSIDIR: Integrated Single Inversion and Double Inversion Recovery

An efficient 3D brain imaging pulse sequence was developed with a pair of inversion pulses that simultaneously acquire both single inversion recovery (SIR) and double inversion recovery (DIR) image data. Sampling was performed using a spoiled gradient echoes with a 3D radial k-space readout. A sliding window reconstruction was used to generate multiple image volumes with different single and double inversion times. The SIR volumes included a nulled gray matter frame and a nulled white matter frames and also more standard T1-weighted contrast. The DIR sampling yielded a gray matter specific map with nulling of both white matter and CSF.

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