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Abstract #1497

Apparent Exchange Rate (AXR) Mapping Using Diffusion MRI: an in vitro and in vivo Feasibility Study on Breast Cancer

Samo Lasic 1 , Savannah C. Partridge 2 , Cheng-Liang Liu 2 , Stina Oredsson 3 , Lao Saal 4 , Daniel Topgaard 5 , Markus Nilsson 6 , and Karin Bryskhe 1

1 CR Development AB, Lund, Sweden, 2 Dept. of Radiology, University of Washington, Seattle Cancer Care Alliance, Seattle, United States, 3 Department of Biology, Lund University, Lund, Sweden, 4 Department of Oncology, Lund University Hospital, Lund, Sweden, 5 Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden, 6 Lund University Bioimaging Center, Lund University, Lund, Sweden

A feasibility study of filter exchange imaging (FEXI) for detection of apparent exchange rate (AXR) was performed on breast cancer cell lines and on a breast tumour patient in vivo. Results suggest that different breast cancer types could be distinguished with FEXI based on their AXR values. The AXR could be determined for the tumour ROI, while in normal tissue the AXR was outside the experimental range. Low SNR did not allow voxel based data analysis. Further optimization of FEXI will be required before FEXI can be evaluated in a larger group of breast cancer patients.

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