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Abstract #1500

Estimation of the arterial input function using accelerated dual-contrast EPIK: a multi-modality MR-PET study

Liliana Caldeira 1 , Seong Dae Yun 1 , Nuno A da Silva 1 , Christian Filss 1 , and N Jon Shah 1,2

1 Institute of Neuroscience and Medicine - 4, Research Centre Jlich GmbH, Jlich, Germany, 2 Department of Neurology, RWTH Aachen University, Aachen, Germany

The arterial input function (AIF) is essential for quantification in MRI and PET imaging. The ground truth for AIF estimation is arterial cannulation. Alternatively, the AIF can be estimated using MRI and/or PET images, but a reasonable temporal resolution of dynamic image series is necessary (<2s). In PET imaging, high temporal resolution is limited (>5s). Here, we propose a method to acquire data for the AIF based on an EPI with keyhole (EPIK) sequence. The EPIK sequence combines both high temporal resolution and high spatial resolution. Furthermore, dual-contrast EPIK (DC-EPIK) can also be acquired to provide additional information.

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