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Abstract #1514

RARE Sequence Optimization Parameters for 19F MRI studies of Labeled Neuronal Stem Cells at 11.7 T

Alfonso Mastropietro 1,2 , Annette Tennstadt 2 , Nadine Henn 2 , Andreas Beyrau 2 , Maria Grazia Bruzzone 3 , Giuseppe Baselli 4 , and Mathias Hoehn 2,5

1 Scientific Direction Unit, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy, 2 In-vivo NMR lab, Max Planck Institute for Neurological Research, Cologne, Germany, 3 Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy, 4 Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy, 5 Department of Radiology, Leiden Medical School, Leiden, Netherlands

Aim of this work is to perform a punctual optimization of RARE parameters for 19F MRI studies of labeled neuronal stem cells. This approach is based on relaxation times estimation and numerical simulations. The optimization approach was evaluated in different biological environments at 11.7T MRI scanner.A correct optimization strategy increases the sensitivity of 19F MRI technique.

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