Abstract #1514
RARE Sequence Optimization Parameters for 19F MRI studies of Labeled Neuronal Stem Cells at 11.7 T
Alfonso Mastropietro 1,2 , Annette Tennstadt 2 , Nadine Henn 2 , Andreas Beyrau 2 , Maria Grazia Bruzzone 3 , Giuseppe Baselli 4 , and Mathias Hoehn 2,5
1
Scientific Direction Unit, Fondazione IRCCS
Istituto Neurologico C. Besta, Milan, Italy,
2
In-vivo
NMR lab, Max Planck Institute for Neurological Research,
Cologne, Germany,
3
Neuroradiology Unit,
Fondazione IRCCS Istituto Neurologico C. Besta, Milan,
Italy,
4
Department
of Electronics, Information and Bioengineering,
Politecnico di Milano, Milan, Italy,
5
Department
of Radiology, Leiden Medical School, Leiden, Netherlands
Aim of this work is to perform a punctual optimization
of RARE parameters for 19F MRI studies of labeled
neuronal stem cells. This approach is based on
relaxation times estimation and numerical simulations.
The optimization approach was evaluated in different
biological environments at 11.7T MRI scanner.A correct
optimization strategy increases the sensitivity of 19F
MRI technique.
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