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Abstract #1520

Compressed Sensing Based J-Resolved Spectroscopic Imaging in Obstructive Sleep Apnea

Manoj Kumar Sarma 1 , Rajakumar Nagarajan 1 , Paul Michael Macey 2 , Ravi Aysola 3 , and M. Albert Thomas 1

1 Radiological Sciences, UCLA School of Medicine, Los Angeles, CA, United States, 2 School of Nursing, UCLA School of Medicine, Los angeles, CA, United States, 3 Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA, United States

Obstructive sleep apnea syndrome (OSAS) is a common sleep disturbance affecting the adult population leading to numerous health problems. Chronic intermittent hypoxic episodes, hypercapnia and transient blood pressure elevation in OSAS may damage neural structures and induce cerebral metabolic changes. Even though many structural imaging studies have shown brain tissue changes in OSAS, only a limited number of MRS based studies can be found so far. In this study, we investigated neurochemical changes in multiple brain regions of OSAS patients using compressed sensing (CS) based Echo-planar J-resolved spectroscopic imaging (EP-JRESI) and quantify the metabolites using prior knowledge fitting (ProFit) algorithm.

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