A fast method for 31 P localised MRS in vivo

31P MRS offers a powerful approach to non-invasively measure extracellular pH (pHe) and intracellular/extracellular pH gradient in vivo. 31P MRS techniques require long acquisition times.The exogenous cell-impermeant 31P reporter 3-aminopropyl phosphonate (3-APP) used for pHe evaluation should be retained within the tumor for the entire duration of the measurements. This condition is not always fulfilled in highly vascularised tumors. We here propose a new technique for fast 31P MRS in highly vascularised tumours by improving the localization of the surface coil (positioned on superficial tumours) with a saturation band which dephases the signal arising from the mouse body.

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