Abstract #1595
Texture Analysis of Muscle 3-Point Dixon Fat-Fraction: Changes Over 1 Year
Christopher D J Sinclair 1,2 , Jasper M Morrow 1 , Arne Fischmann 3 , Michael G Hanna 1 , Mary M Reilly 1 , Tarek A Yousry 1,2 , and John S Thornton 1,2
1
MRC Centre for Neuromuscular Diseases, UCL
Institute of Neurology, London, United Kingdom,
2
Department
of Brain Repair and Rehabilitation, UCL Institute of
Neurology, London, United Kingdom,
3
University
of Basel Hospital, Basel, Switzerland
Fat-water quantification is a promising method for
sensitively measuring changes in muscle in upcoming
clinical trials in neuromuscular diseases. In this work
we applied texture analysis to 3-point Dixon fat
fraction maps to assess fat-infiltration in the
hamstring muscles in 17 patients with the representative
condition inclusion body myositis, measured twice at a 1
year interval. Mean fat-fraction, contrast, homogeneity
run length image texture measures all changed
significantly over 1 year. There were no equivalent
texture parameter changes in a healthy volunteer group
over this period, demonstrating the promise of muscle
fat-fraction texture analysis for measuring longitudinal
fat-infiltration in neuromuscular conditions.
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