Abstract #1674
14 T NMR and 7 T MRI in vitro investigation of cold stimulation of abdominal WAT, inguinal WAT and BAT
Alexander Brunner 1 , Daniela Strzoda 2 , Karel D. Klika 3 , Mathies Breithaupt 1 , Vanessa Stahl 1 , Stephan Herzig 2 , and Armin M. Nagel 1
1
Medical Physics in Radiology, German Cancer
Research Center (DKFZ), Heidelberg, Germany,
2
Molecular
Metabolic Control, German Cancer Research Center (DKFZ),
Heidelberg, Germany,
3
Molecular
Structure Analysis, German Cancer Research Center (DKFZ),
Heidelberg, Germany
Based on its unique thermogenic capacity, brown adipose
tissue (BAT) shows very high potential to serve as a
therapeutic node in the treatment of metabolic
disorders, e.g., obesity. Recently, the BOLD effect
T2*-weighted MRI during cold stimulation was used to
detect cold-activated BAT in human individuals [1]. In
this work, we compared 14 T NMR spectra and, for the
first time, water fat fraction (WFF) [2], T1, T2 values
measured in vitro by 7 T MRI between BAT, inguinal white
adipose tissue (iWAT) and abdominal white adipose tissue
(aWAT) in cold-stimulated mice and normal mice.
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