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Abstract #1691

Effects of Fiber Curvature on Anisotropic Inversions in Waveguide Elastography

Anthony Romano 1 , Varsha Viswanath 2 , Jing Guo 3 , Michael Scheel 3 , Sebastian Hirsch 3 , Jrgen Braun 4 , and Ingolf Sack 3

1 Physical Acoustics, The Naval Research Laboratory, Washington, DC, United States, 2 Department of Biomedical Engineering, University of California at Davis, Davis, CA, United States, 3 Department of Radiology, Charit-Universittsmedizin, Berlin, Germany, 4 Institute of Medical Informatics, Charit-Universittsmedizin, Berlin, Germany

Previously, we introduced a method called Waveguide Elastography and implemented this to analyze the anisotropic stiffnesses of the Corticospinal Tracts of both healthy volunteers and patients suffering from ALS. In these previous studies, we inverted the Orthotropic equations of motion along the local tangent vectors of the fiber tracts. Here, we invert along the principal direction of fiber tracts while including the effects of curvature. It was observed that the effects of curvature in the calculation of the Laplacians bias the inherent stiffness in a similar fashion as wave velocities are altered by an index of refraction in ray theory.

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