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Abstract #1694

Waves as biosensor for microarchitecture

Simon A. Lambert 1,2 , Peter Nashlm 3 , Lauriane Juge 1 , Lynne Bilston 4 , Bojan Guzina 5 , Sverre Holm 3 , and Ralph Sinkus 2

1 INSERM U1149, 1- Center for research on inflammation, Universit Paris 7, Clichy, Ile de france, France, 2 Division of Imaging Sciences and Biomedical Engineering, KCL, BHF Centre of Excellence, london, London, United Kingdom, 3 Informatics Department, University of Oslo, oslo, Norway, 4 University of New South Wales, Neuroscience Research Australia, Randwick, Australia, 5 University of Minnesota, Minneapolis, United States

Recently in vivo experiments using Multifrequency MRE (MMRE) have shown that the exponent of the power law derived from MMRE data fitting with a power law could be more sensitive to specific pathologies such as fibrosis, steatosis or even inflammation. However these works lack fundamental understanding of the relation existing between the tissue microstructure with its macroscopic nature. In this study we develop a full theoretical model of shear wave propagation at the microscopic scale in phantoms containing wave obstacles and demonstrate that shear waves are able to reveal at the macroscopic scale the hidden micro-architectural properties of the material.

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