Abstract #1694
Waves as biosensor for microarchitecture
Simon A. Lambert 1,2 , Peter Nashlm 3 , Lauriane Juge 1 , Lynne Bilston 4 , Bojan Guzina 5 , Sverre Holm 3 , and Ralph Sinkus 2
1
INSERM U1149, 1- Center for research on
inflammation, Universit Paris 7, Clichy, Ile de france,
France,
2
Division
of Imaging Sciences and Biomedical Engineering, KCL, BHF
Centre of Excellence, london, London, United Kingdom,
3
Informatics
Department, University of Oslo, oslo, Norway,
4
University
of New South Wales, Neuroscience Research Australia,
Randwick, Australia,
5
University
of Minnesota, Minneapolis, United States
Recently in vivo experiments using Multifrequency MRE (MMRE)
have shown that the exponent of the power law derived
from MMRE data fitting with a power law could be more
sensitive to specific pathologies such as fibrosis,
steatosis or even inflammation. However these works lack
fundamental understanding of the relation existing
between the tissue microstructure with its macroscopic
nature. In this study we develop a full theoretical
model of shear wave propagation at the microscopic scale
in phantoms containing wave obstacles and demonstrate
that shear waves are able to reveal at the macroscopic
scale the hidden micro-architectural properties of the
material.
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