Abstract #1698
MR elastography of MPTP-induced Parkinsons disease in the mouse
Ingolf Sack 1 , Barbara Steiner 2 , Charlotte Klein 2 , Elisabeth Hain 2 , Kerstin Riek 3 , Jing Guo 3 , and Jrgen Braun 4
1
Radiology, Charit-Universittsmedizin
Berlin, Berlin, Berlin, Germany,
2
Neurology,
Charit-Universittsmedizin Berlin, Berlin, Germany,
3
Radiology,
Charit-Universittsmedizin Berlin, Berlin, Germany,
4
Medical
Informatics, Charit-Universittsmedizin Berlin, Berlin,
Germany
Magnetic resonance elastography (MRE) was applied to a
murine model of neurotoxin-induced Parkinson's disease
and compared to histological findings. For the first
time, a significant increase of cerebral elasticity was
observed in response to disease. We found an increase in
the storage modulus of the brain at day 6 after
treatment with the neurotoxin MPTP which parallels the
proliferation of new neurons predominantly in the
hippocampal region. The results provide insight into the
crucial role of neurons for the constitution of the
viscoelastic matrix and motivate further applications of
MRE in patients as a new biomarker for neurodegenerative
diseases.
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