Abstract #1703
Diffusion-weighted MRI as a biomarker in uncompensated vestibular patients - preliminary results.
Angelique Van Ombergen 1 , Ben Jeurissen 2 , Floris Vanhevel 3 , Wim Van Hecke 4 , Vincent Van Rompaey 5 , Jan Sijbers 2 , Stefan Sunaert 6 , Paul Parizel 3 , Paul van de Heyning 5 , and Floris Wuyts 1
1
Antwerp University Research center for
Equilibrium and Aerospace, University of Antwerp,
Antwerp, Belgium,
2
Vision
Lab, Department of Physics, University of Antwerp,
Antwerp, Belgium,
3
Department
of Radiology, Antwerp University Hospital & University
of Antwerp, Antwerp, Belgium,
4
Icometrix,
Leuven, Belgium,
5
Department
of Otorhinolaryngology and Head and Neck Surgery,
Antwerp University Hospital & University of Antwerp,
Belgium,
6
Department
of Radiology, University Hospital of the Catholic
University of Leuven, Leuven, Belgium
Diffusion parameters in uncompensated vestibular
patients and healthy controls subjects were
investigated. In all subjects multi-shell high angular
resolution diffusion weighted (DW) data were acquired
and we performed tractography. Significant differences
in fractional anisotropy (FA) values were found at the
right parietal operculum 2 and cerebellar peduncles.
Reduced FA in these regions may explain the symptoms of
continuous vertigo and inadequate compensation due to
vestibular lesions. This pilot study suggests that
diffusion parameters may serve as biomarkers for
vestibular induced neuroplasticity and unravel the
relationship between brain connectivity and vestibular
complaints.
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