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Abstract #1706

Real-time MRI of Oropharyngeal Swallowing Function: Initial Clinical Results

Shuo Zhang 1 , Arno Olthoff 2 , Per-Ole Carstens 3 , and Jens Frahm 1

1 Biomedizinische NMR Forschungs GmbH, Max-Planck-Institute for Biophysical Chemistry, Goettingen, Lower Saxony, Germany, 2 Department of Otorhinolaryngology, University Medical Center, Goettingen, Lower Saxony, Germany, 3 Department of Neurology, University Medical Center, Goettingen, Lower Saxony, Germany

Previous studies of swallowing function using conventional clinical methods suffer mainly from invasiveness and limited visualization planes. Here, we applied the recently introduced real-time MRI technique based on undersampled radial FLASH and nonlinear inversion, which provided consecutive T1-images of swallowing actions with an in-plane resolution of 1.5 mm and acquisition times of 41 ms (24 fps) almost free from artifacts. Up to 12 distinct swallowing events with a well-orchestrated temporal pattern could be characterized. Preliminary clinical results with timing quantification showed significant difference between healthy subjects and patients with inclusion body myositis, which promises a useful tool for disease diagnosis.

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