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Abstract #1709

High resolution three dimensional morphometry and nasal air flow of the mammalian nose from multi-modal imaging

Thomas Neuberger 1,2 , Joseph P Richter 3 , Christopher R Rumple 3 , Andrew P Quigley 3 , Allison N Ranslow 3 , Timothy M Ryan 4 , Timothy D Stecko 4 , Benison Pang 5 , Blaire Van Valkenburgh 5 , and Brent A Craven 3

1 Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, United States, 2 Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, United States, 3 Applied Research Laboratory, Pennsylvania State University, University Park, PA, United States, 4 Center for Quantitative X-Ray Imaging, Pennsylvania State University, University Park, PA, United States, 5 Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, United States

This paper presents the current state-of-the-art techniques for reconstructing nasal form and function. The mammalian nasal cavity is a multi-purpose organ that houses a complex arrangement of bony turbinals and a tortuous, interconnected airway in which respiratory air conditioning, filtering of environmental contaminants, and chemical sensing occur. This study combines MRI and CT to build high resolution three dimensional models of the nasal cavity of six different mammals. The reconstructed models were used in computational fluid dynamics (CFD) simulations of nasal airflow. Future CFD simulations may include respiratory heat and moisture exchange and odorant mass transport.

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