Abstract #1712
Detection of GABA, Aspartate and Glutathione in the Human Spinal Cord
Andreas Hock 1,2 , Bertram Wilm 1 , Giorgia Zandomeneghi 3 , Garyfalia Ampanozi 4 , Sabine Franckenberg 4 , Nicola De Zanche 5 , Jurek Nordmeyer-Maner 1 , Spyros S. Kollias 6 , Thomas Kraemer 4 , Michael Thali 4 , Matthias Ernst 3 , and Anke Henning 1,7
1
Institute for Biomedical Engineering,
University and ETH Zurich, Zurich, Zurich, Switzerland,
2
Department
of Psychiatry, Psychotherapy and Psychosomatics Hospital
of Psychiatry, University of Zurich, Zurich, Zurich,
Switzerland,
3
Physical
Chemistry, ETH Zurich, Zurich, Zurich, Switzerland,
4
Institute
of Forensic Medicine, University of Zurich, Zurich,
Zurich, Switzerland,
5
Department
of Medical Physics, Cross Cancer Institute and
University of Alberta, Edmonton, Alberta, Canada,
6
Institute
of Neuroradiology, University Hospital of Zurich,
Zurich, Zurich, Switzerland,
7
Institute
for Biological Cybernetics, Max Planck Institute,
Tuebingen, Baden Wrttemberg, Germany
The aim of this investigation was to expand the number
of predictive markers of in vivo MR spectroscopy
measurements of the human spinal cord. Therefore, data
was acquired in healthy volunteers with sophisticated
motion and instability correction methods as well as
advanced hardware enabling the acquisition with
excellent spectral quality. Aspartate, Glutathione, and
GABA could be additionally identified. In addition, for
the first time, the findings were cross-validated with
those retrieved from a cadaveric spinal cord sample
using high resolution, magic angle spinning NMR
measurements enabling a qualitative indication of the
presence of the additional metabolite markers found in
vivo.
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