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Abstract #1720

Neurite Orientation Dispersion and Density Imaging of the cervical cord in vivo

Francesco Grussu 1 , Torben Schneider 1 , Hui Zhang 2 , Daniel C. Alexander 2 , and Claudia A. M. Wheeler-Kingshott 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom, 2 Department of Computer Science and Centre for Medical Image Computing, University College London, London, England, United Kingdom

Neurite Orientation Dispersion and Density Imaging (NODDI) is a novel diffusion MRI technique providing indices which are appealing biomarkers in diseases of brain and spinal cord. Here, we demonstrate for the first time the application of the full NODDI technique to the healthy cervical cord in vivo, assessing the reproducibility of its metrics and their relationship with Diffusion Tensor Imaging (DTI) indices. The analysis confirmed findings in the brain and demonstrated that NODDI can be a feasible and more specific alternative to DTI for in vivo spinal cord diffusion MRI.

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