Abstract #1720
Neurite Orientation Dispersion and Density Imaging of the cervical cord in vivo
Francesco Grussu 1 , Torben Schneider 1 , Hui Zhang 2 , Daniel C. Alexander 2 , and Claudia A. M. Wheeler-Kingshott 1
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, England, United Kingdom,
2
Department
of Computer Science and Centre for Medical Image
Computing, University College London, London, England,
United Kingdom
Neurite Orientation Dispersion and Density Imaging (NODDI)
is a novel diffusion MRI technique providing indices
which are appealing biomarkers in diseases of brain and
spinal cord. Here, we demonstrate for the first time the
application of the full NODDI technique to the healthy
cervical cord in vivo, assessing the reproducibility of
its metrics and their relationship with Diffusion Tensor
Imaging (DTI) indices. The analysis confirmed findings
in the brain and demonstrated that NODDI can be a
feasible and more specific alternative to DTI for in
vivo spinal cord diffusion MRI.
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