Phase sensitive inversion recovery imaging of the spinal cord in clinical scan times
Nico Papinutto 1 , Valentina Panara 1,2 , Sinyeob Ahn 3 , Kevin Johnson 3 , Regina Schlaeger 1,4 , Eduardo Caverzasi 1 , William Stern 1 , Bruce Cree 1 , Stephen Hauser 1 , and Roland G Henry 1
Dept. of Neurology, UCSF, San Francisco, CA,
- Institute of Advanced Biomedical Technologies,
University "G. D'Annunzio", Chieti, Italy,
Healthcare USA, San Francisco, CA, United States,
of Neurology, University Hospital Basel, University of
Basel, Basel, Switzerland
In this study we present two spinal cord Phase Sensitive
Inversion Recovery (PSIR) imaging protocols that
candidate to be implemented in clinical Multiple
Sclerosis centers. We optimized a 2D and a 3D version of
the same protocol that show great canal/cord, grey
matter/white matter and lesion/cord contrasts, retaining
a good in plane resolution and short acquisition time.
First we show how these protocols provide consistent and
reproducible cord and grey matter area measurement.
Second we show how the 3D version of the protocol
provides a very reliable detection and localization of
MS lesions. The short scan time makes the two proposed
protocols very interesting for clinical environments.
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