Abstract #1742
Microstructural development of human brain cerebral cortex from early 3rd trimester to around the birth with diffusion kurtosis imaging
Tina Jeon 1 , Austin Ouyang 1 , Lina Chalak 2 , Jonathan Chia 3 , Muraleedharan Sivarajan 2 , Greg Jackson 2 , Nancy Rollins 4 , and Hao Huang 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States,
2
Department
of Pediatrics, University of Texas Southwestern Medical
Center, Dallas, Texas, United States,
3
Philips
Medical Systems, Dallas, Texas, United States,
4
Department
of Radiology, Children's Medical Center at Dallas,
Dallas, Texas, United States
From early 3rd trimester to around the birth, active
cellular and molecular processes take place in the human
brain cerebral cortex, resulting in dramatic
microstructural changes. Diffusion kurtosis imaging (DKI)
is capable of characterizing restricted water diffusion
in the brain and has been applied in normal,
developmental and pathological states. In addition, DKI
has been shown to be a more sensitive method than
conventional DTI to quantify gray matter microstructural
changes in adults. In this investigation, we aim to
characterize regional changes in the cortical
microstructure from early 3rd trimester to around the
birth with DKI.
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