Comparison between 7T T2* and 3T MTR in the in vivo human cortex.
Gabriel Mangeat 1 , Sindhuja T. Govindarajan 2 , Caterina Mainero 2 , and Julien Cohen-Adad 1
Biomedical institute, Ecole Polytechnique de
Montreal, Montreal, Qc., Canada,
Martinos Center for Biomedical Imaging, MGH, Harvard
Medical School, MA, United States
T2* at ultra high field MRI (7T) recently prove useful
for characterising cortical myelo-architecture. However,
several confounds hamper the specificity of T2*. Here,
we combined T2* with magnetization transfer data (MTR)
in the same cohort of healthy subjects. The goal was to
assess the relationship between T2* at 7T and MTR at 3T,
and show their respective sensitivity and specificity to
myelin content. Data were preprocessed and then combined
within a surface-based analysis framework. Average
correlation between T2* and MTR was r=-0.76. Combining
other metrics (T1, diffusion, T2w/T1w) within the same
methodological framework could potentially bring useful
insight into myelo-architecture.
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