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Abstract #1786

Exploring the laminar components of the human cortex using ultra-high resolution Inversion Recovery and diffusion

Daniel Barazany 1,2 , Karl Zilles 3 , and Yaniv Assaf 1

1 Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel, 2 CUBRIC School of Psychology, Cardiff University, Cardiff, United Kingdom, 3 Institute of Neuroscience and Medicine INM-1, Research Center Juelich, Jeulich, Germany

Inversion recovery (IR) MRI provide image contrasts that allow the human cortex segmentation to their subcomponents (i.e., IR-layers), based on the intrinsic T1 properties. In this work, several tissue blocks of fixed human cortex were scanned at ultra-high resolution both IR-MRI to visualize their IR layers. In addition, we also acquired different diffusion MRI modalities such as diffusion tensor imaging (DTI) and composite hindered and restricted model of diffusion (CHARMED) to explore the IR-layer diffusion characteristics and their connectivity patterns by tractography analysis.

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