Abstract #1814
4D Flow MRI to quantify cerebral blood flow during environmental challenges
J. Mikhail Kellawan 1 , John W Harrell 1 , Alejandro Roldan-Alzate 2 , Cameron Rousseau 1 , Oliver Wieben 2 , and William G Schrage 1
1
Department of Kinesiology, University of
Wisconsin - Madison, Madison, Wisconsin, United States,
2
Departments
of Medical Physics and Radiology, University of
Wisconsin - Madison, Madison, Wisconsin, United States
Purpose: To quantify total and regional cerebral blood
flow (CBF) in humans to hypoxia and cyclooxygenase
inhibition (Indomethacin). Methods: After baseline scans
(4D flow MRI), subjects breathed 10% oxygen to reduce
arterial saturation (~83%). Hypoxia duration was 10
minutes with 4D PC VIPR scan from min 5-10. Results:
Segmentation quality of angiograms was excellent. CBF
increased with hypoxia; the increase was 3x greater in
women. Indomethacin reduced or increased CBF in a sex
and artery specific manner. Summary: 4D flow MRI can
quantify CBF in the entire cerebrovascular system and
with high spatial resolution and physiologic functional
data.
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