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Abstract #1816

Functional MRI of the visual pathway in conscious, awake marmosets

Jennifer L Ciuchta 1 , ChiaChun Hung 1,2 , Cecil Chern-Chyi Yen 1 , Daniel Papoti 1 , David A Leopold 2 , and Afonso C Silva 1

1 CMU/LFMI/NINDS, National Institutes of Health, Bethesda, MD, United States, 2 SCNI/LN/NIMH, National Institutes of Health, Bethesda, MD, United States

The common marmoset (Callithrix jacchus), a small New World monkey with a highly developed visual cortex, is an emerging model to study primate visual processing. Robust BOLD signals in cortical and subcortical areas are measured while the animals are awake, and actively engaged in the visual stimuli. A custom-printed helmet with embedded surface coils restricted each subjects head movement totally non-invasively. Higher cortical areas in the ventral stream responded more strongly to structured stimuli compared to scrambled controls. Our results demonstrate the promise of using awake behaving marmosets as a model for studying primate vision using fMRI.

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