Abstract #1819

High Resolution Mapping of Intravascular Water Molecule Lifetime in the Rhesus Macaque Brain

Ian J Tagge ^1,2 , Xin Li ¹ , Steven G. Kohama ³ , Christopher D Kroenke ^1,4 , Yosef A Berlow ¹ , Vincent B Warren ⁴ , Theodore R Hobbs ⁴ , Scott A Horrocks ⁴ , Nancy L Cady ⁴ , Jonathan Q Purnell ⁵ , Charles S Springer, Jr. ¹ , and William D Rooney ¹

¹ Advanced Imaging Research Center, Oregon Health & Science University, Portland, Oregon, United States, ² Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, United States, ³ Oregon National Primate Research Center, Hillsboro, Oregon, United States, ⁴ Oregon National Primate Research Center, Oregon, United States, ⁵ Department of Endocrinology, Oregon Health & Science University, Oregon, United States

Feasibility of measuring physiologically important parameters such as blood volume fraction (v _b ) and mean intravascular water molecule lifetime ( lower case Greek tau

_b ) with pharmacokinetic modeling of 3D GRE DCE-MRI data is investigated. Parametric maps are presented for healthy adult Rhesus Macaque brain tissue. High parameter precision (evaluated by Monte Carlo simulation) is achieved in all tissues and parameters evaluated. 3D GRE acquisition offers advantages over common qT ₁ techniques including faster acquisition time and greater tissue coverage. These parameters are potentially powerful biomarkers in the study of neurovascular diseases and therapies.

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