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Abstract #1825

Mapping the dynamic relationship between cerebral blood flow and BOLD fluctuations: Implications for quantitative fMRI

Aaron Benjamin Simon 1 and Richard Buxton 2

1 Bioengineering, University of California San Diego, La Jolla, CA, United States, 2 Radiology, University of California San Diego, La Jolla, CA, United States

In this work we measured the blood flow and BOLD responses to visual stimuli, the strength of which were varied sinusoidally at several temporal frequencies. Our goal was to determine whether the function that mapped flow to BOLD responses was unique, or whether it depended on the frequency or phase of the stimulus. We found that the mapping from flow to BOLD had little dependence on the stimulus frequency or phase but that the mapping function was not unique between stimulus on and off periods, suggesting that slow changes in volume or metabolism may complicate the dynamic flow-BOLD relationship.

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