Hypercapnia effects on spontaneous low frequency fluctuations using RS-fMRI
Olga Marshall 1 , Jinsoo Uh 2 , Daniel Lurie 3 , Hanzhang Lu 2 , Michael P. Milham 4 , and Yulin Ge 1
1Radiology/Center for Biomedical Imaging,
New York University School of Medicine, New York, NY,
Imaging Research Center, University of Texas
Southwestern Medical Center, Texas, United States,
Mind Institute, New York, United States,
S Kline Institute for Psychiatric Research, New York,
Carbon dioxide (CO2) is a potent vasodilator, its effect
on brain cerebral blood flow and blood oxygenation level
dependent (BOLD) signal changes has been well-studied.
However, the influence on resting-state fMRI data is
still largely unknown. In this study, we presented the
results of both connectivity and amplitude changes of
default mode network (DMN) under hypercapnia (mixed 5%
CO2, 21% O2, and 74% N2) versus normocapnia condition at
rest in healthy brains. We demonstrated that although
the intrinsic correlation of the DMN at rest during CO2
remains, there is significantly reduced amplitude
(measured with fractional low frequency fluctuations or
fALFF) within DMN connectivity under hypercapnia.
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