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Abstract #1832

Changes of brain activities and metabolites in the right dorsolateral prefrontal cortex in patients with obsessive compulsive disorder

Shin-Eui Park 1 and Gwang-Woo Jeong 1,2

1 Chonnam National University, Interdisciplinary Program of Biomedical Engineering, Gwangju, Chonnam, Korea, 2 Chonnam National University Hospital, Chonnam National University, Department of Radiology, Medical School, Gwangju, Korea

The obsessive compulsive symptoms are mainly related to the dysfunctional cortico-striatal-thalamic circuit (CSTC), a network involving the prefrontal cortex, striatum, thalamus in pathogenesis. Several neuroimaging or spectroscopy studies revealed differential brain activation patterns during performing memory tasks and metabolic concentration changes in the CSTC circuits. However, the findings from the studies mentioned above have not been consistent. We performed 1H MRS and fMRI study during the implicit memory tasks for the quantification of the brain metabolites and identification of the brain activation patterns in OCD patients.

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