Abstract #1837
Altered functional connectivity of rhesus brain during increasing levels of sevoflurane: a resting-state fMRI study on 3T
Yuan Xiao 1 , Peilin Lv 2 , Su Lui 1 , Min Wu 1 , Yuqing Wang 3 , Bin Liu 2 , and Qiyong Gong 1
1
Radiology, Huaxi MR Research Center,
Chengdu, Sichuan, China,
2
Anesthesiology,
West China Hospital of Sichuan University, Chengdu,
Sichuan, China,
3
Radiology,
West China Hospital of Sichuan University, Chengdu,
Sichuan, China
In spite of many years research, the exact mechanism
of how anesthetics modulate the cerebral function is
still unknown. One possible mechanism is that
anesthetics could influence the synchrony of neuronal
networks as reflected by studies on rats, though the
results were controversial 1, 2. However, it is still
unclear whether such effects would be observed in rhesus
monkeys which are closer to human than rats. Moreover,
most previous animal studies were performed at a single
anesthetic dose rather than graded levels of anesthesia;
the latter one can potentially reveal the dose-dependent
alterations of functional connectivity (FC). Thus,
present study aimed to investigate alteration of FC in
rhesus monkeys at different concentrations of
sevoflurane (1.0, 1.3, 1.6 MAC) using resting-state
fMRI.
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