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Abstract #1842

Bilateral functional connectivity for complex finger movements declines as aging: an fMRI and SEM exploration

Sachiko Kiyama 1 , Mitsunobu Kunimi 1 , Tetsuya Iidaka 2 , and Toshiharu Nakai 1

1 National Center for Geriatrics and Gerontology, Ohbu, Japan, 2 Nagoya University, Nagoya, Japan

The present study attempted to seek age related declines of functional connectivity within the motor cortices, with particular focus on the effect of movement complexity. fMRI and SEM (structural equation modeling) were utilized to compare neural activity between younger and elderly groups during the visually guided bimanual finger movement task with easier symmetrical mode and complex asymmetrical one. Results revealed age-related differences in functional connectivity within bilateral PMd and that between bilateral SPL during the task, suggesting that the elderlyfs inaccuracy of complex finger movements in tune with visual information derives from declines in bilateral connectivity within these regions.

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