Abstract #1848
Comparison of standardized and normalized rCBV to differentiate astrocytic brain tumors
Mona M Al-Gizawiy 1 , Melissa A Prah 1 , Peter S LaViolette 1 , Wade M Mueller 2 , and Kathleen M Schmainda 1,3
1
Radiology, Medical College of Wisconsin,
Milwaukee, Wisconsin, United States,
2
Neurosurgery,
Medical College of Wisconsin, Milwaukee, Wisconsin,
United States,
3
Biophysics, Medical College of
Wisconsin, Wisconsin, United States
Perfusion imaging is an invaluable tool for brain tumor
characterization. Relative cerebral blood volume (rCBV)
maps provide insight into brain tumor vascularization.
The purpose of this study was to compare standardized (sRCBV)
and normalized (nRCBV) measures in conjunction with
intraoperative navigation and tissue diagnosis for
astrocytoma grading. Preoperative imaging was
co-registered to intraoperative surgical navigation
scans, and rCBV values were calculated for each tissue
sampling site. sRCBV showed greater potential in
differentiating astrocytic tumors than nRCBV. This study
highlights the importance of perfusion imaging in brain
tumor characterization.
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