Abstract #1852
Assessment of Bevacizumab Treatment Response in High Grade Gliomas using Intravoxel Incoherent Motion (IVIM): A Comparison with Multi-Echo DSC-MRI
Jack T Skinner 1,2 , Paul L Moots 3 , and C Chad Quarles 1,2
1
Radiology and Radiological Sciences,
Vanderbilt University Medical Center, Nashville, TN,
United States,
2
Institute
of Imaging Science, Vanderbilt University Medical
Center, Nashville, TN, United States,
3
Neurology,
Vanderbilt University Medical Center, Nashville, TN,
United States
Traditional methods for measuring brain tumor perfusion
rely on contrast agent injections. Recently, intravoxel
incoherent motion (IVIM) MRI, a non-contrast method,
demonstrated sensitivity to tumor perfusion.
Non-contrast based perfusion biomarkers of treatment
response may be valuable, however, the effect of
longitudinal treatment on IVIM acquisitions is unknown.
IVIM data was collected in high grade glioma patients
receiving bevacizumab and compared to DSC-MRI. In
responsive patients, the IVIM signal became more
monoexponential, with a robust decrease in CBV and CBF.
Further investigation of IVIM characteristics, including
the number of tumor voxels suitable for analysis, may
provide validation for monitoring tumor treatment.
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