Validation of oxygenation and perfusion sensitive MRI methods in healthy brain and brain tumor in mice by invasive micro probe measurements.
Jan Sedlacik 1 , Matthias Reitz 2 , Nils O Schmidt 2 , and Jens Fiehler 1
Neuroradiology, University Medical Center
Hamburg-Eppendorf (UKE), Hamburg, Germany,
University Medical Center Hamburg-Eppendorf (UKE),
Non-invasive assessment of (patho-) physiological
parameters, such as perfusion, oxygenation and oxygen
metabolism is of great importance for the
characterization of pathologies, e.g. tumors, which may
be helpful to better predict treatment response and
potential outcome. MRI methods sensitive to blood
oxygenation and perfusion were validated in healthy mice
brain and mice with brain tumors by subsequent invasive
micro probe measurements during different free breathing
conditions (air, air+10% CO2 and 100% O2).
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