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Abstract #1917

Dissociation Pattern in Resting-State Default Mode Network Connectivity in Type II Diabetes Patients

Ying Cui 1 , Yun Jiao 1 , Pei-Cheng Li 1 , Bing Luo 1 , Hai-Dong Zhu 1 , Cheng-yu Peng 1 , and Gao-Jun Teng 1

1 Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospita, Nanjing, Jiangsu, China

Type 2 diabetes mellitus (T2DM) has been shown to be associated with an increased risk of dementia. However, the etiology underlying is still largely unknown. The default-mode network (DMN) is an important brain network which supports several key functions. Dysfunction of DMN has been suggested as an early marker of several psychiatric disorders. This study aimed to investigate the integrity of the DMN by using independent component analysis (ICA) in T2DM patients and to correlate the DMN functional connectivity (FC) changes with neurocognitive performance and clinical variables. The disrupted DMN could help imply the mechanism linking T2DM and cognitive impairment.

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