Abstract #1922
A Longitudinal Study In Huntingtons Disease Reveals Differential Macro- and Micro-structural Effects
Jessica J Steventon 1,2 , Da Ma 3,4 , Manual J Cardoso 4 , Marc Modat 4 , Mark F Lythgoe 3,4 , Sebastian Ourselin 4 , Rebecca Trueman 2,5 , Anne E Rosser 2 , and Derek K Jones 1
1
Cardiff University Brain Research Imaging
Centre (CUBRIC), Cardiff, Wales, United Kingdom,
2
Brain
Repair Group, Cardiff University, Cardiff, Wales, United
Kingdom,
3
Centre
for Advanced Biomedical Imaging (CABI), University
College London, London, United Kingdom,
4
Centre
for Medical Image Computing (CMIC), University College
London, London, United Kingdom,
5
Nottingham
University, Nottingham, United Kingdom
Patient studies in Huntingtons Disease (HD) are limited
by the incompatibility of MRI with chorea, producing an
incomplete picture of neuropathological changes at later
disease stages. Here, we used both T2-weighted and
diffusion MRI in a mouse model of HD at a
pre-symptomatic and symptomatic time-point, where
anaesthesia is necessary during scanning but eliminates
chorea-related motion artefacts. We apply automated
atlas-based segmentation and diffusion tractography for
the first time in a knock-in mouse model of HD and find
that macro-structural changes preceded micro-structural
changes, suggesting microstructural abnormalities may be
a downstream effect of grey matter abnormalities in HD.
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