Abstract #1935
White matter damage in MCI converters and non converters to AD: a longitudinal study using probabilistic tractography
Elena Makovac 1 , Laura Serra 1 , Barbara Span 1 , Giovanni Giulietti 1 , Mario Torso 1 , Mara Cercignani 1,2 , Carlo Caltagirone 3,4 , and Marco Bozzali 1
1
Neuroimaging Laboratory, IRCCS Santa Lucia
Foundation, Rome, Italy,
2
Clinical
Imaging Sciences Centre, Brighton and Sussex Medical
School, United Kingdom,
3
Department
of Clinical and Behavioural Neurology, IRCCS Santa Lucia
Foundation, Rome, Italy,
4
Department
of Neuroscience, University of Rome Tor Vergata, Italy
Patients with amnestic mild cognitive impairment (aMCI)
are known to have a higher risk of convertion to AD than
healthy elderly subjects. In this longitudinal study, we
used probabilistic tractography to perform a multiple
DTI index analysis of the principal association, limbic
and commissural WM tracts known to be involved by AD
pathology. Subtle changes in brain structure associated
with disease progression were remarkably more evident in
aMCI converters than MCI non converters. These findings
suggest that both primary myelin breakdown and axonal
loss occur over AD evolution, and different patterns may
account for different stages between preclinical and
clinical AD.
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