Abstract #1952
Controlling for white matter hyperintensities in cross-sectional voxel-wise diffusion MRI studies of aging
C. M. Barth 1 , D. A. Bennett 2 , and K. Arfanakis 1
1
Department of Biomedical Engineering,
Illinois Institute of Technology, Chicago, Illinois,
United States,
2
Rush
Alzheimer's Disease Center, Rush University Medical
Center, Chicago, Illinois, United States
Brain white matter hyperintense lesions (WMHs) are
common in older adults. When diffusion imaging is used
to investigate brain microstructure in cross-sectional
voxel-wise studies of aging, it is necessary to control
for the effects of WMHs on the diffusion parameters.
This is often accomplished by including in statistical
models a measure of the total volume of WMHs, which is
problematic. The purpose of this study was to test the
hypothesis that controlling for the presence of WMHs
(binary mask), allows more sensitive detection of other
microstructural abnormalities compared to controlling
for the total volume of WMHs.
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