Meeting Banner
Abstract #1952

Controlling for white matter hyperintensities in cross-sectional voxel-wise diffusion MRI studies of aging

C. M. Barth 1 , D. A. Bennett 2 , and K. Arfanakis 1

1 Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, United States, 2 Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States

Brain white matter hyperintense lesions (WMHs) are common in older adults. When diffusion imaging is used to investigate brain microstructure in cross-sectional voxel-wise studies of aging, it is necessary to control for the effects of WMHs on the diffusion parameters. This is often accomplished by including in statistical models a measure of the total volume of WMHs, which is problematic. The purpose of this study was to test the hypothesis that controlling for the presence of WMHs (binary mask), allows more sensitive detection of other microstructural abnormalities compared to controlling for the total volume of WMHs.

This abstract and the presentation materials are available to members only; a login is required.

Join Here